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Human p22 BID recombinant protein

Cat.#: 502249

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Product Information

  • Product Name
    Human p22 BID recombinant protein
  • Documents
  • Description
    The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
  • Protein name
    BH3-interacting domain death agonist
  • Protein short names
    MGC42355; AU022477; 2700049M22RIK; MGC15319; AI875481; BID; FP497
  • Uniprot ID
    P55957
  • Gene Name
    BID
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human BID isoform 1 (P55957-1) (Met 1-Asp 195) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human BID consists of 197 amino acids and migrates as an approximately 22 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized human BID at 10 μg/mL (100 μl/well) can bind  biotinylated human BCL2L1, The EC50 of biotinylated human BCL2L1 is 7.1 ng/mL.
    3. Immobilized human BID at 10 μg/mL (100 μl/well) can bind  biotinylated mouse BCL2L1, The EC50 of biotinylated mouse BCL2L1 is 5.6 ng/mL.
  • Validations

    Human BID Protein SDS-PAGE

    Human BID Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"