Bestrophin-1 antibody

Bestrophin-1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Bestrophin-1 Rabbit Polyclonal antibody. Positive WB detected in Transfected HEK-293 cells.

ELISA, WB

Human; other species not tested.

ARB antibody; BEST antibody; BEST1 antibody; bestrophin 1 antibody; Bestrophin-1 antibody; BMD antibody; TU15B antibody; VMD2 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_004183). Purification method: Antigen affinity purified.

Polyclonal

0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).