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BCL6 antibody

Cat.#: 108429

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Product Information

  • Product Name
    BCL6 antibody
  • Documents
  • Description
    BCL6 Rabbit Polyclonal antibody. Positive WB detected in Raji cells. Positive IP detected in Raji cells. Positive IHC detected in human lymphoma tissue, human tonsillitis tissue. Observed molecular weight by Western-blot: 80 kDa
  • Tested applications
    ELISA, WB, IP, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    B cell CLL/lymphoma 6 antibody; B cell lymphoma 5 protein antibody; B cell lymphoma 6 protein antibody; BCL6 antibody; LAZ3 antibody; Protein LAZ 3 antibody; ZBTB27 antibody; Zinc finger protein 51 antibody; ZNF51 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of BCL6 recombinant protein (Accession Number: NM_001130845). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

    IHC: 1:50-1:500

  • Validations

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:117102(BCL6 Antibody) at dilution of 1:400 (under 10x lens). heat mediated antigen retrieved with Sodium Citrate buffer (pH6).

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:117102(BCL6 Antibody) at dilution of 1:400 (under 10x lens). heat mediated antigen retrieved with Sodium Citrate buffer (pH6).

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:117102(BCL6 Antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Sodium Citrate buffer (pH6).

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:117102(BCL6 Antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Sodium Citrate buffer (pH6).

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:117102(BCL6 Antibody) at dilution of 1:1500

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:117102(BCL6 Antibody) at dilution of 1:1500

    IP Result of anti-BCL6 (IP:Catalog No:117102, 4ug; Detection:Catalog No:117102 1:1000) with Raji cells lysate 1400ug.

    IP Result of anti-BCL6 (IP:Catalog No:117102, 4ug; Detection:Catalog No:117102 1:1000) with Raji cells lysate 1400ug.

  • Background
    BCl6, a zinc finger transcription factor, contains a N-terminal BTB/POZ domain and C-terminal zinc finger DNA-binding motifs and represses transcription of a wide range of target proteins and microRNAs. BCL6 protein has been reported as a master regulator of B lymphocyte development and growth, and altered BCL6 protein expression was implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL). BCL6 is required for the development of T follicular helper T cells (TFH), a helper T cell subset required for the formation of mature and productive GCs. BCL6 has also been shown to play important regulatory roles in macrophages.
  • References
    • Shi Y, Xu LZ, Peng K. Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine. Scientific reports. 5:17651. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"