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Product Name
BCL11A antibody
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Description
BCL11A Rabbit Polyclonal antibody. Positive IHC detected in human gliomas.
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Tested applications
ELISA, IHC
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
BCL11A antibody; HBFQTL5 antibody; CTIP1 antibody; FLJ34997 antibody; KIAA1809 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of BCL11A recombinant protein (Accession Number: NM_018014). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:108389(BCL11A antibody) at dilution of 1:50 (under 10x lens)
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Background
B-CELL CLL/LYMPHOMA 11A(BCL11A)is a highly conserved zinc finger gene. It acts as a myeloid and B-cell proto-oncogene, and may play key roles in leukemogenesis and hematopoiesis. It is an essential factor in lymphopoiesis, and required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. It is also involved in lymphoid malignancies through translocation or amplification events. It has recently been shown that BCL11A expression is inversely correlated with γ globin expression.(PMID:21156846). This is a rabbit polyclonal antibody raised against part chain of N-terminal BCL11A of human origin. There are three isoforms of BCL11A: isoform1(773aa), isoform2(486aa) and isoform3(239aa)
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