BCAS3 antibody

BCAS3 antibody

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• Material Safety Data Sheets (MSDS)

BCAS3 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, MCF7 cells. Observed molecular weight by Western-blot: 74kd

ELISA, WB

Human,Mouse,Rat; other species not tested.

BCAS3 antibody; DKFZp686O1527 antibody; FLJ20128 antibody; GAOB1 antibody; MAAB antibody; Protein Maab1 antibody; Rudhira antibody

Rabbit IgG

This antibody was obtained by immunization of BCAS3 recombinant protein (Accession Number: BC001250). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Rudhira/BCAS3 (Breast Cancer Amplified Sequence 3) is a conserved protein expressed in the embryonic vasculature and malignant tumors. Rudhira is a predicted WD40 domain protein. During mouse development Rudhira is expressed in erythropoietic and angiogenic precursors but not in their differentiated progeny. This transient expression of Rudhira is also seen in normal adult angiogenesis. BCAS3, the human ortholog of Rudhira is 98% identical and the gene maps to a breakpoint of hematological neoplasms on chromosome 17q23.1. BCAS3 is also expressed in vascular development in embryoid bodies in vitro and was originally identified as a gene over-expressed in breast cancers. It is reported to be a target of metastasis associated protein-1 (MTA-1). Further BCAS3 expression is also upregulated in grade III and IV glioblastomas where it is misexpressed in the tumor cells.