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Human BCAM / CD239 (Fc Tag) recombinant protein

Cat.#: 500451

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Product Information

  • Product Name
    Human BCAM / CD239 (Fc Tag) recombinant protein
  • Documents
  • Description
    The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.
  • Protein name
    Basal cell adhesion molecule
  • Protein short names
    LU; AU; BCAM; MSK19; B-CAM; 1200005K12RIK; GPLU; CD239
  • Uniprot ID
    P50895
  • Gene Name
    BCAM; LU; MSK19
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human BCAM (NP_005572.2) (Met 1-Ala 547) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human BCAM/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 754 amino acids and predicts a molecular mass of 83 kDa. As a result of glycosylation, the rh BCAM/Fc monomer migrates as approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human BCAM Protein (Fc Tag) SDS-PAGE

    Human BCAM Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"