Rhesus BTLA (Fc Tag) recombinant protein

Rhesus BTLA (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

B-and T-lymphocyte attenuator isoform 1

A630002H24; CD272; B- AND T-LYMPHOCYTE-ASSOCIATED PROTEIN; B AND T LYMPHOCYTE ATTENUATOR; B- AND T-LYMPHOCYTE ATTENUATOR; BTLA1

G7MKA9

BTLA; EGK_11287

Human Cells

A DNA sequence encoding the rhesus BTLA (EHH16054.1) (Met1-Leu155) was expressed with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus BTLA comprises 366 amino acids and has a calculated molecular mass of 41.4 KDa.

> 90 % as determined by SDS-PAGE

Immobilized cynoBTLA-Fc at 10 μg/ml (100 μl/well) can bind biotinylated cynoTNFRSF14-Fc (Cat:504769), EC₅₀ of biotinylated cynoTNFRSF14-Fc (Cat:504769) is 0.7-1.64 μg/ml.