Human Azurocidin / CAP37 (His Tag) recombinant protein

Human Azurocidin / CAP37 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Azurocidin

CAP37; AZAMP; AZU1; HUMAZUR; AZUROCIDIN; NAZC; HBP; AZU

P20160

AZU1

Human Cells

A DNA sequence encoding the human AZU1 (NP_001691.1) (Met 1-Pro 250) with a C-terminal polyhistidine tag was expressed.

Human

The secreted recombinant human AZU1 comprises 235 amino acids with a predicted molecular mass of 25.6 kDa. As a result of glycosylation, rh AZU1 migrates as an approximately 37 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE