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  • AXIN2 antibody

AXIN2 antibody

Cat.#: 108518

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Product Information

  • Product Name
    AXIN2 antibody
  • Documents
  • Description
    AXIN2 Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue, mouse lung tissue. Observed molecular weight by Western-blot: 93-100kd
  • Tested applications
    ELISA, WB
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    AXIN2 antibody; DKFZp781B0869 antibody; axin 2 antibody; Axin like protein antibody; Axis inhibition protein 2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of AXIN2 recombinant protein (Accession Number: BC006295). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:117079(AXIN2 antibody) at dilution of 1:200

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:117079(AXIN2 antibody) at dilution of 1:200

  • Background
    Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidoman scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutaion is involved in colorectal cancer. Catalgo#20540-1-AP is a rabbit polyclonal antibdy raised against a 34 amino acid N-terminal of human AXIN2.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"