AXIN2 Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue, mouse lung tissue. Observed molecular weight by Western-blot: 93-100kd
human, mouse, rat; other species not tested.
AXIN2 antibody; DKFZp781B0869 antibody; axin 2 antibody; Axin like protein antibody; Axis inhibition protein 2 antibody
This antibody was obtained by immunization of AXIN2 recombinant protein (Accession Number: BC006295). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:117079(AXIN2 antibody) at dilution of 1:200
Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidoman scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutaion is involved in colorectal cancer. Catalgo#20540-1-AP is a rabbit polyclonal antibdy raised against a 34 amino acid N-terminal of human AXIN2.
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