ATPIF1 antibody

ATPIF1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ATPIF1 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 12 kDa

ELISA, WB, IP, IF

Human, Mouse; other species not tested.

ATPase inhibitory factor 1 antibody; ATPI antibody; ATPIF1 antibody; ATPIP antibody; IF(1) antibody; IF1 antibody; Inhibitor of F(1)F(o) ATPase antibody

Rabbit IgG

This antibody was obtained by immunization of ATPIF1 recombinant protein (Accession Number: NM_016311). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The H(+)-ATP synthase is a reversible engine of mitochondria that synthesizes or hydrolyzes ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and progression of diverse human pathologies. ATPIF1 gene encodes mitochondrial ATPase Inhibitory Factor 1 (IF1), also named ATPI, ATPIP or IP. Endogenous IF1 limits ATP depletion when the mitochondrial membrane potential falls below a threshold and the ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis, thus supporting an oncogenic role of IF1 in cancer.

• Ivanes F, Faccenda D, Gatliff J. The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. British journal of pharmacology. 171(18):4193-206. 2014.