ATP5J antibody

ATP5J antibody

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• Material Safety Data Sheets (MSDS)

ATP5J Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, human heart tissue, mouse heart tissue, mouse liver tissue. Positive IHC detected in human osteosarcoma tissue. Observed molecular weight by Western-blot: 9 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

ATP5 antibody; ATP5A antibody; ATP5J antibody; ATPase subunit F6 antibody; ATPM antibody; CF6 antibody

Rabbit IgG

This antibody was obtained by immunization of ATP5J recombinant protein (Accession Number: NM_001003697). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ATP5J, also known as coupling factor 6 (CF6), is a soluble integral component of mitochondrial ATP synthase. Mitochondrial ATP synthase is a multi-subunit membrane-bound enzyme that catalyzes the synthesis of ATP by utilizing a proton electrochemical gradient. It consists of three domains, namely the extrinsic and intrinsic membrane domains (F1 and F0, respectively) joined by a stalk.CF6 is one of the subunits in the stalk and an essential component for energy transduction. Recently CF6 has also been reported to play a crucial role in the development of insulin resistance and hypertension. CF6 is first synthesized as an immature form in the cytosol, then transported to the mitochondria by an import signal peptide and becomes an active form with the signal peptide cleaved. Western blot analysis of CF6 demonstrates a single band around 9 kDa to 12 kDa in various tissues including heart, liver, brain and HUVEC (human umbilical vein endothelial cells).