ATP11C Polyclonal Antibody

ATP11C Polyclonal Antibody

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• Material Safety Data Sheets (MSDS)

Polyclonal antibody to ATP11C

WB

Human, Mouse

ATP11C antibody; ATPIG antibody; ATPIQ antibody; phospholipid-transporting ATPase IG antibody

Rabbit IgG

Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 430-650 of human ATP11C (NP_775965.2).

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

WB 1:500 - 1:2000

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).