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Product Name
ATOH1 antibody
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Description
ATOH1 Rabbit Polyclonal antibody. Positive WB detected in Neuro-2a cells, mouse small intestine tissue. Observed molecular weight by Western-blot: 38kd,45kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ATH1 antibody; ATOH1 antibody; atonal homolog 1 (Drosophila) antibody; bHLHa14 antibody; HATH1 antibody; MATH 1 antibody; Protein atonal homolog 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ATOH1 recombinant protein (Accession Number: NM_005172). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
Neuro-2a cells were subjected to SDS PAGE followed by western blot with Catalog No:108335(ATOH1 Antibody) at dilution of 1:600
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Background
ATOH1, also named as Protein atonal homolog 1 or BHLHA14, is a 364 amino acid protein, which contains 1 bHLH (basic helix-loop-helix) domain. ATOH1,as a transcriptional regulator in the nucleus activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. ATOH1 plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
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References
- Tailor J, Kittappa R, Leto K. Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(30):12407-22. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"