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Product Name
Human Aspartate aminotransferase / GOT1 (His Tag) recombinant protein
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Description
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
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Protein name
Aspartate aminotransferase, cytoplasmic
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Protein short names
ASPARTATE AMINOTRANSFERASE; GIG18; TRANSAMINASE A; SOLUBLE; GOT-1; CCAT; CYTOPLASMIC; GLUTAMIC-OXALOACETIC TRANSAMINASE 1; CYTOPLASMIC; GLUTAMATE OXALOACETATE TRANSAMINASE 1; ASTQTL1; CASPAT; GROWTH-INHIBITING PROTEIN 18; AI789014; GOT1; CYTOSOLIC ASPARTATE AMINOTRANSFERASE; SOLUBLE (ASPARTATE AMINOTRANSFERASE 1)
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Uniprot ID
P17174
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Gene Name
GOT1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human GOT1 (P17174) (Met1-Gln413) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GOT1 consists of 428 amino acids and predicts a molecular mass of 48.1 KDa. It migrates as an approximately 36-45 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human GOT1 / Aspartate aminotransferase Protein (His Tag) SDS-PAGE
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