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  • [Asn670,Leu671]-Amyloid β//A4 Protein Precursor770 (667-675) peptide

[Asn670,Leu671]-Amyloid β//A4 Protein Precursor770 (667-675) peptide

Not For Human Use, Lab Use Only.

Cat.#: 314298

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 113.8 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    [Asn670,Leu671]-Amyloid β//A4 Protein Precursor770 (667-675) peptide
  • Documents

    Batch to batch variation of the purity

  • Quantity/Unit
    1 Vial
  • Sequence
    SEVNLDAEF
  • Three letter code
    Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    96.7%
  • Molecular Formula
    C44H66N10O18
  • Molecular Weight
    1023.07
  • Source
    Synthetic
  • Additional Information
    SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-SEVNLDAEF-OH
  • Chemical Formula:C44H66N10O18
  • Sequence length:9
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:-0.24
  • Mw average:1023.04
  • Theoretical pI:2.94
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"