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Product Name
ASIP Polyclonal Antibody
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Description
Polyclonal antibody to ASIP
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Tested applications
IHC, IF
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Species reactivity
Mouse, Rat
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Alternative names
ASIP antibody; AGSW antibody; AGTI antibody; AGTIL antibody; ASP antibody; SHEP9 antibody; agouti-signaling protein antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IHC 1:50 - 1:100
IF 1:50 - 1:100 -
Validations
Immunohistochemistry - ASIP Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using ASIP antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - ASIP Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using ASIP antibody at dilution of 1:100 (40x lens).
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Background
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"