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ASGR2 antibody

Cat.#: 108227

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Product Information

  • Product Name
    ASGR2 antibody
  • Documents
  • Description
    ASGR2 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue. Positive IP detected in L02 cells. Positive FC detected in HepG2 cells. Observed molecular weight by Western-blot: 39 kDa
  • Tested applications
    ELISA, WB, IP, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    ASGP R antibody; ASGP R 2 antibody; ASGPR 2 antibody; ASGR2 antibody; asialoglycoprotein receptor 2 antibody; CLEC4H2 antibody; Hepatic lectin H2 antibody; HL 2 antibody; Hs.1259 antibody; L H2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of ASGR2 recombinant protein (Accession Number: XM_005256648). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IP: 1:200-1:1000

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:108227(ASGR2 antibody) at dilution of 1:400

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:108227(ASGR2 antibody) at dilution of 1:400

    IP Result of anti-ASGR2 (IP:Catalog No:108227, 4ug; Detection:Catalog No:108227 1:300) with L02 cells lysate 1800ug.

    IP Result of anti-ASGR2 (IP:Catalog No:108227, 4ug; Detection:Catalog No:108227 1:300) with L02 cells lysate 1800ug.

    1X10^6 HepG2 cells were stained with 0.2ug ASGR2 antibody (Catalog No:108227, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

    1X10^6 HepG2 cells were stained with 0.2ug ASGR2 antibody (Catalog No:108227, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

  • Background
    Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"