• AS10 peptide

AS10 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319296

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Optional Service: TFA RemovalWhat's this?

Special Price 152.9 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    AS10 peptide
  • Documents
  • Sequence
    H-KLKKIAQKIKNFFQKLVP-OH
  • Three letter code
    H-Lys-Leu-Lys-Lys-Ile-Ala-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-Val-Pro-OH
  • Length (aa)
    18
  • Peptide Purity (HPLC)
    95.18%
  • Molecular Formula
    C105H179N27O22
  • Molecular Weight
    2171.7
  • Source
    Synthetic
  • Additional Information
    Peptide AS10 is a derivative of the Mouse Cathelicidin-Related Antimicrobial Peptide (CRAMP) that has been found to inhibit the formation of fungal and bacterial biofilms. It has been shown to be non-toxic to human osteoblasts, mesenchymal stromal cells, and endothelial cells, and does not affect their functionality. Therefore, it is an interesting lead molecule for the development of a biofilm-preventive coating for implants. AS10 may be used to prevent biofilm formation on implants, which can lead to infections and other complications.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • De Brucker K, Delattin N, Robijns S, Steenackers H, Verstraeten N, Landuyt B, Luyten W, Schoofs L, Dovgan B, Fröhlich M, Michiels J, Vanderleyden J, Cammue BP, Thevissen K. Derivatives of the mouse cathelicidin-related antimicrobial peptide (CRAMP) inhibit fungal and bacterial biofilm formation. Antimicrob Agents Chemother. 2014 Sep;58(9):5395-404. doi: 10.1128/AAC.03045-14. Epub 2014 Jun 30. PMID: 24982087; PMCID: PMC4135870.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"