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Product Name
ARPC1B antibody
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Description
ARPC1B Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer.
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Tested applications
ELISA, IHC
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
ARPC1B antibody; p41 ARC antibody; Arp2/3 complex 41 kDa subunit antibody; p40 ARC antibody; ARC41 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ARPC1B recombinant protein (Accession Number: XM_006715825). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:108164(ARPC1B antibody) at dilution of 1:100 (under 25x lens)
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Background
ARPC1B also known as ARC41, p41-ARC, or p40-ARC, is one of seven subunits of the human Arp2/3 protein complex, that belongs to the SOP2 family. ARPC1B localizes on centrosomes and has a distinct role in centrosomal homeostasis. ARPC1B is both a physiological activator and substrate of Aurora A kinase, and these interactions help to maintain mitotic integrity in mammalian cells. In recent resaeach, ARPC1B is selected as a candidate prediction marker for sensitivity of Choroidal malignant melanomas to radiotherapy.
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References
- van Dekken H, Tilanus HW, Hop WC. Array comparative genomic hybridization, expression array, and protein analysis of critical regions on chromosome arms 1q, 7q, and 8p in adenocarcinomas of the gastroesophageal junction. Cancer genetics and cytogenetics. 189(1):37-42. 2009.
- Auzair LB, Vincent-Chong VK, Ghani WM. Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC). European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"