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ARK5 antibody

Cat.#: 108194

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Product Information

  • Product Name
    ARK5 antibody
  • Documents
  • Description
    ARK5 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue, human heart tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 74 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    AMPK related protein kinase 5 antibody; ARK5 antibody; KIAA0537 antibody; NUAK family SNF1 like kinase 1 antibody; NUAK1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of ARK5 recombinant protein (Accession Number: NM_014840). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:108194(NUAK1 Antibody) at dilution of 1:600

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:108194(NUAK1 Antibody) at dilution of 1:600

    Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using Catalog No:108194(NUAK1 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using Catalog No:108194(NUAK1 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using Catalog No:108194(NUAK1 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using Catalog No:108194(NUAK1 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    NUAK1 is a member of the human adenosine monophosphate (AMP)-activated protein kinase family that has been identified as a key tumor cell survival factor. It is also named as ARK5, KIAA0537, OMPHK1 and belongs to the protein kinase superfamily. The physiological role of NUAK1 is potentially to suppress glucose uptake through negative regulation of insulin signaling in oxidative muscle. This protein has 2 isoforms produced by alternative splicing.
  • References
    • Esteve-Puig R, Gil R, González-Sánchez E. A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS genetics. 10(10):e1004721. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"