Product Name

ARHGEF16 antibody

Documents

Description

ARHGEF16 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in mouse kidney tissue. Observed molecular weight by Western-blot: 80 kDa

Tested applications

ELISA, IHC, WB

Species reactivity

Human, Mouse; other species not tested.

Alternative names

ARHGEF16 antibody; GEF16 antibody; NBR antibody

Isotype

Rabbit IgG

Preparation

This antibody was obtained by immunization of ARHGEF16 recombinant protein (Accession Number: XM_024446454). Purification method: Antigen affinity purified.

Clonality

Polyclonal

Formulation

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions

Store at -20℃. DO NOT ALIQUOT

Applications

Recommended Dilution:

WB: 1:200-1:1000

IHC: 1:20-1:200

Validations

mouse kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:108184(ARHGEF16 antibody) at dilution of 1:100

Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:108184(ARHGEF16 antibody) at dilution of 1:50 (under 25x lens)

Background

Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades, mitogenesis, transcriptional activation and stimulation of DNA synthesis. Rho proteins cycle between a biologically active GTP-bound state and an inactive GDP-bound state. Rho guanine nucleotide exchange factor (GEF) has a crucial role in activating small GTPase by exchange GDP for GTP. ARGEF16 is one of the multiple GEF members. Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions.

References

Lee J, Park B, Kim G. Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation. Biochimica et biophysica acta. 1843(11):2438-47. 2014.

ARHGEF16 antibody

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