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Product Name
ARHGEF11 Polyclonal Antibody
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Description
Polyclonal antibody to ARHGEF11
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Tested applications
WB, IHC
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Species reactivity
Human, Mouse, Rat
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Alternative names
ARHGEF11 antibody; GTRAP48 antibody; PDZ-RHOGEF antibody; rho guanine nucleotide exchange factor 11 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human ARHGEF11
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:100 -
Validations
Western blot - ARHGEF11 Polyclonal Antibody
Western blot analysis of extracts of mouse brain, using ARHGEF11 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.
Immunohistochemistry - ARHGEF11 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using ARHGEF11 antibody (40x lens).
Immunohistochemistry - ARHGEF11 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human lung using ARHGEF11 antibody (40x lens).
Immunohistochemistry - ARHGEF11 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human colon using ARHGEF11 antibody (40x lens).
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Background
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"