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Product Name
ARHGEF10 antibody
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Description
ARHGEF10 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 68kd, 75kd, 148-152kd
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Tested applications
ELISA, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ARHGEF10 antibody; DKFZp686H0726 antibody; GEF10 antibody; KIAA0294 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ARHGEF10 recombinant protein (Accession Number: BC036809). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:108183(ARHGEF10 antibody) at dilution of 1:50 (under 10x lens)
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Background
ARHGEF10(Rho guanine nucleotide exchange factor 10), also named as KIAA0294, is a member of the family of Rho guanine nucleotide exchange factors (GEFs), which are implicated in neural morphogenesis and connectivity and regulate the activity of small Rho GTPases by catalyzing the exchange of bound GDP by GTP(PMID:14508709). The deduced 1,121-amino acid protein shares significant similarity with cell signaling proteins(PMID:9205841). Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV)(PMID:14508709). It has 5 isoforms produced by alternative splicing.
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