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Product Name
AR-23 peptide (TFA removed)
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Documents
Batch to batch variation of the purity
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Sequence Shortening
AIGSILGALAKGLPTLISWIKNR-NH2
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Sequence
H-Ala-Ile-Gly-Ser-Ile-Leu-Gly-Ala-Leu-Ala-Lys-Gly-Leu-Pro-Thr-Leu-Ile-Ser-Trp-Ile-Lys-Asn-Arg-NH2
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Length (aa)
23
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Peptide Purity (HPLC)
98.84%
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Molecular Formula
C111H190N30O28
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Molecular Weight
2392.8
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Source
Synthetic
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Form
Powder
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Description
C-terminal NH2. AR-23 has Antibacterial, Antifungal, Anticancer activity. AR-23 was found in Rana tagoi, Asia.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Chianese A, Iovane V, Zannella C, Capasso C, Nastri BM, Monti A, Doti N, Montagnaro S, Pagnini U, Iovane G, De Filippis A, Galdiero M. Synthetic Frog-Derived-like Peptides: A New Weapon against Emerging and Potential Zoonotic Viruses. Viruses. 2023 Aug 24;15(9):1804. doi: 10.3390/v15091804. PMID: 37766211; PMCID: PMC10537403.
- Chianese A, Zannella C, Monti A, De Filippis A, Doti N, Franci G, Galdiero M. The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23. Int J Mol Sci. 2022 Jan 14;23(2):883. doi: 10.3390/ijms23020883. PMID: 35055066; PMCID: PMC8779559.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Peptide Property
- Analysed Sequence:H-AIGSILGALAKGLPTLISWIKNR-OH
- Chemical Formula:C111H190N30O28
- Sequence length:23
- Extinction coefficient:5690 M-1cm-1
- GRAVY:0.73
- Mw average:2392.87
- Theoretical pI:11.65
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"