APC antibody

APC antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

APC Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human colon cancer tissue, human colon tissue, human endometrial cancer tissue.

ELISA, IHC

Human,Mouse,Rat; other species not tested.

adenomatous polyposis coli antibody; APC antibody; BTPS2 antibody; Deleted in polyposis 2.5 antibody; DP2 antibody; DP2.5 antibody; DP3 antibody; Protein APC antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000038). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

APC, also named as DP2.5, belongs to the adenomatous polyposis coli (APC) family. APC is a tumor suppressor that regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division, and associates with other proteins involved in cell attachment and signaling. APC promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. It plays a critical role in several cellular processes. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. APC activity is correlated with its phosphorylation state. Defects in APC are a cause of familial adenomatous polyposis (FAP) which includes also Gardner syndrome (GS). Defects in APC are a cause of hereditary desmoid disease (HDD) which also known as familial infiltrative fibromatosis (FIF). Defects in APC are a cause of medulloblastoma (MDB) which is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) which also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1).