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  • Apamin (Uniprot P01500) peptide

Apamin (Uniprot P01500) peptide

For research use only. We do not sell to patients.

Cat.#: 318903

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Optional Service: TFA RemovalWhat's this?

Special Price 613.63 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Apamin (Uniprot P01500) peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-CNCKAPETALCARRCQQH-Amidation
  • Three letter code
    H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-Amidation
  • Length (aa)
    18
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C79H135N31O24S4
  • Molecular Weight
    2027.36
  • Source
    Synthetic
  • Additional Information
    H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1-11, 3-15) The apamin sequence has been synthesized by the solid-phase procedure. The synthetic peptide showed the same physicochemical and chemical properties as natural apamin in the following tests: paper electrophoresis, amino acid analyses after acid and enzymatic hydrolyses, sequence analysis, electrophoreses after tryptic and chymotryptic digestions. Synthetic apamin was as active as natural apamin in the neurotoxic assay in mice (LD50, after subcutaneous injection, for the 20-g mouse: 58 μg).
  • Storage Guidelines
    Ideally Apamin (Uniprot P01500) peptide should be stored in a freezer at or below -9C. Apamin (Uniprot P01500) peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Sandberg BE, Ragnarsson U. Solid phase synthesis of apamin, the principal neurotoxin in bee venom. Isolation and characterization of acetamidomethyl apamin. Int J Pept Protein Res. 1978 Mar;11(3):238-45. PMID: 649258.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-CNCKAPETALCARRCQQH-Amidation
  • Chemical Formula:C79H135N31O24S4
  • Sequence length:18
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:-0.73
  • Mw average:2031.36
  • Theoretical pI:8.31
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"