Antimicrobial peptide zp37
For research use only. We do not sell to patients.
Cat.#: 318880
Optional Service:
TFA RemovalWhat's this?
Special Price 94.5 USD
Availability:
1-2 weeks
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Product Name
Antimicrobial peptide zp37
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Quantity/Unit
1 Vial
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Sequence
H-GIKAKIIIKIKK-Amidation
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Three letter code
H-Gly-Ile-Lys-Ala-Lys-Ile-Ile-Ile-Lys-Ile-Lys-Lys-Amidation
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Length (aa)
12
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Peptide Purity (HPLC)
95.2
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Molecular Formula
C65H126N18O12
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Molecular Weight
1351.8
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Source
Synthetic
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Additional Information
The antimicrobial peptide zp37 (GIKAKIIIKIKK-NH2), which possesses a helical structure, was found to exhibit a minimum inhibitory concentration (MIC) value of 16 μM on E. coli O157:H7, effectively killing such strain in vitro and reducing its population size by 94.7% in sprouts upon storage for seven days. In sprouts, zp37 treatment reduced 94.7% E. coli O157:H7 upon storage for 7 days. zp37 caused membrane depolarization and weak membrane permeabilization. zp37 bound to the DNA of E. coli O157:H7, causing DNA aggregation and precipitation.
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Storage Guidelines
Ideally Antimicrobial peptide zp37 should be stored in a freezer at or below -9C. Antimicrobial peptide zp37 should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Lanhua Yi, Ping Zeng, Jun Liu, Kwok-Yin Wong, Edward Wai-Chi Chan, Yanbing Lin, Kin-Fai Chan, Sheng Chen. Antimicrobial peptide zp37 inhibits Escherichia coli O157:H7 in alfalfa sprouts by inflicting damage in cell membrane and binding to DNA, LWT, Volume 146, 2021, 111392, ISSN 0023-6438
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About TFA salt
Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.
TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.
TFA Removal Service is recommended for:
- Peptides that will be used in cellular assays
- Peptides that will be used as APIs or in manufactured products
- For hydrophilic peptides containing numerous basic residues
Peptide Property
- Analysed Sequence:H-GIKAKIIIKIKK-Amidation
- Chemical Formula:C65H126N18O12
- Sequence length:12
- Extinction coefficient:0 M-1cm-1
- GRAVY:0.37
- Mw average:1351.8
- Theoretical pI:11.12
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
Red: Hydrophobic uncharged residues, like F I L M V W A and P
Blue: Basic residues, like R K H and N-terminal -NH2
Green: Acidic residues, like D E and C-terminal -COOH
Black: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"