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Product Name
Anti-XLF Rabbit antibody
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Description
XLF Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
XLF antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human XLF
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/5000
ICC/IF: 1/50
FC: 1/20
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Validations
Western blot detection of XLF in K562,Hela cell lysates using XLF Rabbit pAb(1:1000 diluted).Predicted band size:33kDa.Observed band size:39kDa.
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Background
Swiss-Prot Acc.Q9H9Q4.DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666).
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