Anti-XIAP antibody

Anti-XIAP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human XIAP

ELISA, IHC-P, ICC/IF, IF

Human XIAP/BIRC4

1110015C02Rik antibody; Aipa antibody; Api3 antibody; API3 antibody; Birc4 antibody; BIRC4 antibody; IAP3 antibody; ILP1 antibody; ILP-1 antibody; MIHA antibody; MIHA antibody; mXIAP antibody; RP1-315G1.5 antibody; RP23-207E14.3 antibody; Xiap antibody; XIAP antibody; XLP2 antibody; API3 antibody; ILP1 antibody; MIHA antibody; XLP2 antibody; BIRC4 antibody; IAP-3 antibody; hIAP3 antibody; hIAP-3 antibody; Aipa antibody; Api3 antibody; IAP3 antibody; MIHA antibody; Birc4 antibody; ILP-1 antibody; 1110015C02Rik antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human XIAP/BIRC4 . XIAP/BIRC4 specific IgG was purified by Human XIAP/BIRC4 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

E3 ubiquitin-protein ligase XIAP / BIRC4, also known as inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.