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Product Name
Anti-WAVE 1 Rabbit antibody
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Description
WAVE 1 Rabbit polyclonal antibody
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Tested applications
WB, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
WAVE; SCAR1; WAVE1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human WAVE 1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
FC: 1/50
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Validations
Western blot detection of WAVE 1 in Rat Brain,C6,3T3,Hela cell lysates using WAVE 1 Rabbit pAb(1:1000 diluted).Predicted band size:62kDa.Observed band size:90kDa.
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Background
Swiss-Prot Acc.Q92558.Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex . As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"