Anti-WAP5 / WFDC2 / HE4 antibody

Anti-WAP5 / WFDC2 / HE4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to WAP5 / WFDC2 / HE4

IHC-P

Human WFDC2 / HE4
No cross-reactivity in ELISA with Rat WFDC2

HE4 antibody; WFDC2 antibody; 1600023A02Rik antibody; dJ461P17.6 antibody; EDDM4 antibody; HE4 antibody; MGC57529 antibody; RP23-140D14.5 antibody; RP3-461P17.2 antibody; WAP5 antibody; WAP5 antibody; Wfdc2 antibody; HE4 antibody; WAP5 antibody; EDDM4 antibody; dJ461P17.6 antibody; HE4 antibody; WAP5 antibody; 1600023A02Rik antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human WFDC2 / HE4 (rh WFDC2 / HE4; NP_006094.3; Met1-Phe124).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein which contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

• Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73.
• Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700.
• Bingle,L. et al., 2006, Respir Res. 7 : 61.
• Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53.
• Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.