Anti-VE-Cadherin/CD144 antibody

Cat.#: 105223

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Product Information

  • Product Name
    Anti-VE-Cadherin/CD144 antibody
  • Documents
  • Description
    Mouse monoclonal to VE-Cadherin/CD144
  • Tested applications
    FCM
  • Species reactivity
    Human VE-Cadherin / CD144 / CDH5
  • Alternative names
    7B4 antibody; CD144 antibody; 7B4 antibody; Vec antibody; VECD antibody; Cd144 antibody; VEcad antibody; VE-Cad antibody; AA408225 antibody; 7B4 antibody; 7B4 antibody; AA408225 antibody; Cd144 antibody; CD144 antibody; Cdh5 antibody; CDH5 antibody; FLJ17376 antibody; Vec antibody; VE-Cad antibody; VE-Cadherin antibody; VE-Cadherin antibody; VECD antibody
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VE-Cadherin / CD144 / CDH5 (rh VE-Cadherin / CD144 / CDH5; CAA56306.1; Met1-Gln593) and conjugated with APC under optimum conditions, the unreacted APC was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    VE-Cadherin / CD144 / CDH5 Antibody, Mouse MAb, Flow Cytometry

    VE-Cadherin / CD144 / CDH5 Antibody, Mouse MAb, Flow Cytometry

    Flow cytometric analysis of Human CD144 expression on HUVEC cells. Cells were stained with APC-conjugated anti-Human CD144. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
  • References
    • Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
    • Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
    • Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
    • Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
    • Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"