Anti-VDR antibody

Anti-VDR antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human VDR

IHC-P, ICC/IF, IF

Human VDR-NR111

nuclear receptor subfamily 1 group I member 1 antibody; vitamin D3 receptor antibody; 25-dihydroxyvitamin D3 receptor antibody; 25-dihydroxyvitamin D3 receptor antibody; NR111 antibody; Nr1i1 antibody; nuclear receptor subfamily 1 group I member 1 antibody; vitamin D nuclear receptor variant 1 antibody; vitamin D3 receptor antibody; NR1I1 antibody; PPP1R163 antibody; Nr1i1 antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human VDR-NR111, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor family. VDRs repress expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. VDR is expressed in the intestine, thyroid and kidney and has a vital role in calcium homeostasis. It is the nuclear hormone receptor, also called transcription factor that mediates the action of vitamin D3. Inherited mutations in the VDR gene leads to rickets.