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Product Name
Anti-VDAC1 Rabbit antibody
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Description
VDAC1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P
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Species reactivity
Human, Mouse, Rat
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthesized peptide derived from human VDAC1
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Clonality
Polyclonal
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Formulation
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/500-1/2000
IHC: 1/50-1/200
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Validations
Western blot analysis of VDAC1 expression in C2C12,THP-1,3T3,Jurakt and Hela cell lysates using VDAC1 antibody at 1/1000 dilution.Predicted band size:31KDa.Observed band size:31KDa.
Immunohistochemical analysis of paraffin-embedded human liver, using VDAC1 Antibody.
Western blot analysis of Calreticulin expression in (1) HepG2 cell lysate; (2) Jurkat cell lysate.
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Background
Swiss-Prot Acc.P21796.Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"