Anti-TSG101 Rabbit antibody

Cat.#: 167554

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Product Information

  • Product Name
    Anti-TSG101 Rabbit antibody
  • Documents
  • Description
    TSG101 Rabbit polyclonal antibody
  • Tested applications
    WB, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    TSG10; VPS23 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human TSG101
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/2000

    IP: 1/20

  • Validations

    Western blot detection of TSG101 in K562 cell lysates using TSG101 Rabbit pAb(1:1000 diluted).Predicted band size:44KDa.Observed band size:44KDa.

    Western blot detection of TSG101 in K562 cell lysates using TSG101 Rabbit pAb(1:1000 diluted).Predicted band size:44KDa.Observed band size:44KDa.

  • Background
    Swiss-Prot Acc.Q99816.Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"