Anti-TROP-2/TACSTD2 antibody

Anti-TROP-2/TACSTD2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to TROP-2/TACSTD2

IHC-P

Mouse TROP-2 / TACSTD2
Has cross-reactivity in ELISA with Human TROP2

EGP1 antibody; GP50 antibody; M1S1 antibody; EGP-1 antibody; TROP2 antibody; GA7331 antibody; GA733-1 antibody; Ly97 antibody; EGP-1 antibody; TROP2 antibody; C80403 antibody; GA733-1 antibody; C80403 antibody; EGP1 antibody; EGP-1 antibody; EGP-1 antibody; GA7331 antibody; GA733-1 antibody; GA733-1 antibody; GP50 antibody; Ly97 antibody; M1S1 antibody; MGC141612 antibody; MGC141613 antibody; TACSTD2 antibody; TROP2 antibody; TROP2 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TROP-2 / TACSTD2 (rM TROP-2 / TACSTD2; Q8BGV3; Met1-Gln270).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

• Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
• Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.