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Product Name
Anti-TNFSF13 antibody
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Description
Rabbit polyclonal to TNFSF13
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Tested applications
WB, IHC-P
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Species reactivity
Human APRIL/cd256
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Alternative names
APRIL antibody; 2310026N09Rik antibody; a proliferation-inducing ligand antibody; a proliferation-inducing ligand antibody; April antibody; APRIL antibody; CD256 antibody; RP23-422L16.1 antibody; CD256 antibody; TALL2 antibody; ZTNF2 antibody; TALL-2 antibody; Tall2 antibody; TRDL-1 antibody; UNQ383/PRO715 antibody; April antibody; Tall2 antibody; Trdl1 antibody; 2310026N09Rik antibody; TALL2 antibody; TALL-2 antibody; TNF- and APOL-related leukocyte expressed ligand 2 antibody; Trdl1 antibody; TRDL-1 antibody; tumor necrosis factor ligand superfamily member 13 antibody; tumor necrosis factor ligand superfamily member 13 antibody; tumor necrosis factor-like protein ZTNF2 antibody; tumor necrosis factor-related death ligand-1 antibody; UNQ383/PRO715 antibody; ZTNF2 antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human APRIL/cd256, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
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Validations
APRIL / cd256 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
APRIL / cd256 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human cd256 in human colon carcinoma with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
APRIL / cd256 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human cd256 in human prostate with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
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Background
TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF17/BCMA. TNFSF13 is lowly expressed in normal tissues, but is elevated in several types of tumors and transformed cell lines. It is mportant for B cell development. TNFSF13 may also play a role in T-independent type II antigen responses and T cell survival, and induce proliferation/survival of non lymphoid cells. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T- and B-cell regulatory effects. TNFSF13 also has been demonstrated to bind to proteoglycans on the cell surface.
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References
- Bossen C, et al. (2007) BAFF, APRIL and their receptors: structure, function and signaling. Semin. Immunol. 18(5):263-75.
- Tangye SG, et al. (2007) BAFF, APRIL and human B cell disorders. Immunol. 18(5): 305-17.
- Osman W, et al. (2012) Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. PLoS One. 7(4):e32683.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"