Anti-TEF1/TEAD-1 Rabbit antibody

Anti-TEF1/TEAD-1 Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TEF1/TEAD-1 Rabbit monoclonal antibody

WB, FC

Human, Mouse, Rat

AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1 antibody

Rabbit IgG

Antigen: A synthetic peptide of human TEAD-1

Monoclonal

50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P28347.Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.