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  • Anti-TEAD1/TEAD2/TEAD3/TEAD4 Rabbit antibody

Anti-TEAD1/TEAD2/TEAD3/TEAD4 Rabbit antibody

Cat.#: 168859

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-TEAD1/TEAD2/TEAD3/TEAD4 Rabbit antibody
  • Documents
  • Description
    TEAD1/TEAD2/TEAD3/TEAD4 Rabbit monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human TEAD4
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:1000

  • Validations

    Western blot detection of TEAD1/TEAD2/TEAD3/TEAD4 in K562,Hela cell lysates using TEAD1/TEAD2/TEAD3/TEAD4 Rabbit mAb(1:1000 diluted).Predicted band size:49kDa.Observed band size:54kDa.

    Western blot detection of TEAD1/TEAD2/TEAD3/TEAD4 in K562,Hela cell lysates using TEAD1/TEAD2/TEAD3/TEAD4 Rabbit mAb(1:1000 diluted).Predicted band size:49kDa.Observed band size:54kDa.

  • Background
    Swiss-Prot Acc.Q15561.Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"