Anti-TCF-4/TCF7L2 Rabbit antibody

Cat.#: 168597

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-TCF-4/TCF7L2 Rabbit antibody
  • Documents
  • Description
    TCF-4/TCF7L2 Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse, Rat
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human TCF-4
  • Clonality
    Monoclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:5000

    1:50

    1:50

    1:20

    1:20

  • Validations

    Western blot detection of TCF-4 in K562,Hela cell lysates using TCF-4 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:68kDa.

    Western blot detection of TCF-4 in K562,Hela cell lysates using TCF-4 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:68kDa.

  • Background
    Swiss-Prot Acc.Q9NQB0.Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"