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Product Name
Anti-SRFBP1 (p49/STRAP) antibody
- Documents
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Description
Rabbit polyclonal to SRFBP1 (p49/STRAP)
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Tested applications
WB, IP
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Species reactivity
Human SRFBP1 (p49 / STRAP)
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Alternative names
serum response factor binding protein 1 antibody; SRFBP1 antibody; BUD22 antibody; P49 antibody; Rlb1 antibody; STRAP antibody; p49/STRAP antibody; BUD22 homolog antibody; SRF-dependent transcription regulation associated protein antibody; serum response factor binding protein 1 antibody; SRFBP1 antibody; 2810036K01Rik antibody; p49/STRAP antibody; SRF-dependent transcription regulation associated protein antibody; P49 antibody; Rlb1 antibody; BUD22 antibody; STRAP antibody; p49/STRAP antibody; p49/STRAP antibody; 2810036K01Rik antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human SRFBP1 (p49 / STRAP) (rh SRFBP1 (p49 / STRAP); Q8NEF9; Met1-Asp429). SRFBP1 (p49 / STRAP) specific IgG was purified by Human SRFBP1 (p49 / STRAP) affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/ml
IP: 1-4 μg/mg of lysate
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Validations
SRFBP1 (p49 / STRAP) Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
SRFBP1 (p49 / STRAP) Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
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Background
SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. SRFBP1 negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. SRFBP1 may be involved in regulating transcriptional activation of cardiac genes during the aging process. It also may play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
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References
- Datta PK, et al. (1999) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 273(52):34671-4.
- Datta PK, et al. (1998) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 273(52):34671-4.
- Datta PK, et al. (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol. 20(9):3157-67.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"