Anti-Spike antibody

Cat.#: 142569

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Product Information

  • Product Name
    Anti-Spike antibody
  • Documents
  • Description
    Rabbit Polyclonal to MERS-CoV Spike
  • Tested applications
    WB, ELISA, IP
  • Species reactivity
    MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1
  • Alternative names
    S antibody; S antibody; S1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 . MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 specific IgG was purified by MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 0.5-5 μg/ml

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1.

  • Validations

    MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"