Anti-SPARCL1 / SPARC-like 1 antibody

Cat.#: 106654

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Product Information

  • Product Name
    Anti-SPARCL1 / SPARC-like 1 antibody
  • Documents
  • Description
    Rabbit monoclonal to SPARCL1 / SPARC-like 1
  • Tested applications
    FCM
  • Species reactivity
    Human SPARCL1
  • Alternative names
    Ecm2 antibody; extracellular matrix protein 2 antibody; hevin antibody; hevin antibody; hevin) antibody; hevin) antibody; mast9 antibody; SC1 antibody; mast9 antibody; PIG33 antibody; proliferation-inducing protein 33 antibody; Sc1 antibody; Sparcl1 antibody; SPARCL1 antibody; SPARC-like 1 (mast9 antibody; SPARC-like 1 (mast9 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human SPARCL1 (rh SPARCL1; NP_004675.3; Met 1-Phe 664) and conjugated with PE under optimum conditions, the unreacted PE was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    SPARCL1 Antibody (PE), Rabbit MAb, Flow cytometric

    SPARCL1 Antibody (PE), Rabbit MAb, Flow cytometric

    Profile of anti-SPARCL1 reactivity on HL60 cells analyzed by flow cytometry.

  • Background
    SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. In addition, SPARCL1 can influence the function of astroglial cells in the developing and mature central nervous system (CNS).
  • References
    • Sullivan MM, et al. (2004) Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family. Int J Biochem Cell Biol. 36(6): 991-6.
    • Esposito I, et al. (2007) Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer. Neoplasia. 9(1): 8-17.
    • Weimer JM, et al. (2008) A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system. Glia. 56(9): 935-41.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"