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Product Name
Anti-Sox2 antibody
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Description
Rabbit monoclonal to Sox2
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Tested applications
IHC-P
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Species reactivity
Human Sox2
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the N-terminus of the human Sox2.
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 1-10 μg/mL
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Validations
Sox2 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of human SOX2 in human brain with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Sox2 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of human SOX2 in human testis with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
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Background
SOX2, also known as ANOP3, is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. SOX2 is critical for early embryogenesis and for embryonic stem cell pluripotency. It keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Defects in SOX2 can cause microphthalmia, syndromic, 3. A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
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References
- Lu Y, et al., 2010, PLoS ONE. 5(6): e11022.
- Gontan C, et al., 2008, Dev. Biol. 317 (1): 296-309.
- Shi W, et al., 2006, J. Biol. Chem. 281 (33): 23319-25.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"