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Product Name
Anti-Sorcin antibody
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Description
Rabbit polyclonal to Sorcin
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Tested applications
WB, IP
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Species reactivity
Human Sorcin / SRI
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Alternative names
SCN antibody; V19 antibody; CP22 antibody; CP-22 antibody; Sor antibody; 2210417O06Rik antibody; 2900070H08Rik antibody; 22 kDa protein antibody; 2210417O06Rik antibody; 2900070H08Rik antibody; calcium binding protein amplified in mutlidrug-resistant cells antibody; CP22 antibody; CP-22 antibody; H_RG167B05.1 antibody; SCN antibody; Sor antibody; Sorcin antibody; Sorcin antibody; Sri antibody; SRI antibody; V19 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human Sorcin / SRI (rh Sorcin / SRI; P30626; Met1-Val198). Sorcin / SRI specific IgG was purified by Human Sorcin / SRI affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
IP: 1-4 μg/mg of lysate
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Validations
Sorcin / SRI Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Sorcin / SRI Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
Immunochemical staining of human MAPK14 in human placenta with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Sorcin was originally identified in multidrug-resistant cells. It is a alcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Sorcin is overexpressed in the multi-drug resistant chinese hamster ovary cell line CHRC5 and a variety of multidrug-resistant tumor cell lines, but overexpression is not a sufficient or necessary condition for the acquisition of the multidrug-resistant phenotype.
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References
- Meyers MB, et al. (1995) Association of sorcin with the cardiac ryanodine receptor. J Biol Chem. 270(44):26411-8.
- Brownawell AM, et al. (1997) Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). J Biol Chem. 272(35):22182-90.
- Hansen, et al. (2003) The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. FEBS Lett. 545(2-3):151-4.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"