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Product Name
Anti-SNRPD3 Rabbit antibody
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Description
SNRPD3 Rabbit polyclonal antibody
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Tested applications
WB, FC
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Species reactivity
Human
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Alternative names
SMD3; Sm-D3 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human SNRPD3
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/2000
FC: 1/20-1/100
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Validations
Western blot detection of SNRPD3 in C6, Hela cell lysates using SNRPD3 Rabbit pAb(1:1000 diluted).Predicted band size:14kDa.Observed band size:14kDa.
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Background
Swiss-Prot Acc.P62318.Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"