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Product Name
Anti-SerpinI2 antibody
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Description
Mouse monoclonal to SerpinI2
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Tested applications
IHC-P
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Species reactivity
Human SerpinI2
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Alternative names
1810006A24Rik antibody; PI14 antibody; MEPI antibody; PANCPIN antibody; Serpini2 antibody; SerpinI2 antibody; Spi14 antibody; TSA2004 antibody; MEPI antibody; PI14 antibody; PANCPIN antibody; TSA2004 antibody; Spi14 antibody
- Immunogen
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Isotype
Mouse IgG2a
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Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinI2 (rh SerpinI2; NP_006208.1; Met1-Leu405). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 0.5-3 μg/mL
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Validations
SerpinI2 Antibody, Mouse MAb, Immunohistochemistry
Immunochemical staining of human SERPINI2 in human pancreas with mouse monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified. Serpin-I2, also known as myoepithelium-derived serine protease inhibitor, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI14, SERPINI2 and MEPI, is a secreted protein which belongs to the serpin family. It is expressed in pancreas and adipose tissues. SERPINI2 deficiency directly results in the acinar cell apoptosis and malabsorption.
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References
- Riewald M. et al., 1995, J. Biol. Chem. 270: 26754-7.
- Forsyth, S. et al., 2003, Genomics 81: 336-45.
- Horvath, AJ. et al., 2004, J. Mol. Evol. 59: 488-97.
- Loftus,S.K. et al., 2005, PLoS Genet. 1 (3):e38.
- Steenbakkers PJ. et al., 2008, Mycol. Res. 112 (Pt 8): 999-1006.
- Przygodzka, P. et al., 2010, BMC Cell Biol. 11: 30.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"