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Product Name
Anti-SerpinB8 antibody
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Description
Rabbit polyclonal to SerpinB8
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Tested applications
ELISA, IP
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Species reactivity
Mouse SERPINB8 / SerpinB8
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Alternative names
CAP2 antibody; CAP2 antibody; CAP-2 antibody; NK10 antibody; PI8 antibody; SerpinB8 antibody; SerpinB8 antibody; Spi8 antibody; NK10 antibody; ovalbumin antibody; ovalbumin antibody; PI8 antibody; CAP2 antibody; CAP2 antibody; Spi8 antibody; CAP-2 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse SerpinB8 (rM SerpinB8; NP_035589.1; Met 1-Pro 374). SerpinB8 specific IgG was purified by Mouse SerpinB8 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 1-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse SERPINB8. The detection limit for Mouse SERPINB8 is approximately 0.00245 ng/well.
IP: 0.5-2 μg/mg of lysate
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Validations
SerpinB8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
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Background
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Mouse SerpinB8, also known as Cytoplasmic antiproteinase 2, Peptidase inhibitor 8, SerpinB8, PI-8, SERPINB8 and CAP2, is a member of the Serpin superfamily. SERPINB8 was broadly expressed. In normal neuroendocrine tissues, strongest SerpinB8 expression was detected in islets of Langerhans of the pancreas. Moderate SerpinB8 expression was observed in neuroendocrine cells of the thyroid, adrenal cortex, colon, and pituitary gland. In the pancreas, SerpinB8 is specifically expressed by insulin-producing beta cells, and can be used as an additional diagnostic immunohistochemical marker. Mouse SerpinB8 distribution alters during kidney regeneration, possibly to control a prohormone convertase involved in inflammation or tissue repair.
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References
- Sumi, Y. et al., 1989, J. Biochem. 106: 703-7.
- Rawlings, N.D. et al., 2004, Biochem J. 378: 705-16.
- Gillard, A. et al., 2006, Am J Nephrol. 26 (1): 34-42.
- Filleur, S. et al., 2009, J Cell Biochem. 106 (5): 769-75.
- de Koning, P.J. et al., 2009, Pancreas. 38 (4): 461-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"