Anti-SERPINB3 antibody

Anti-SERPINB3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Monoclonal to Human SERPINB3

IP

Human SERPINB3 / SCCA-1

SCCA1 antibody; clade B (ovalbumin) antibody; protein T4-A antibody; SCCA-PD antibody; serpin B3 antibody; member 3 antibody; serine (or cysteine) proteinase inhibitor antibody; squamous cell carcinoma antigen 1 antibody; T4-A antibody; HsT1196 antibody; SCC antibody; SCCA-1 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human SERPINB3 / SCCA-1 .

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.