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Product Name
Anti-SAFB Rabbit antibody
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Description
SAFB Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human SAFB
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000
1:100
1:20
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Validations
Western blot detection of SAFB in K562,3T3,Hela cell lysates using SAFB Rabbit mAb(1:1000 diluted).Predicted band size:103kDa.Observed band size:150kDa.
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Background
Swiss-Prot Acc.Q15424.Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing . Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter . Can inhibit cell proliferation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"